The Future of Non-Invasive Angiogenic Therapy Using Acoustic Waves.

patients with severe angina pectoris for the first time.5,6 In addition, low-energy SW therapy improves the walking ability of patients with PAD and intermittent claudication.7 Ultrasound, another type of acoustic wave, is widely used for ultrasound diagnostic devices and also applied clinically at high intensity to tumor ablation, related mainly to its thermal effect. Recently, low-intensity pulsed ultrasound (LIPUS) was reported to exert angiogenic effects in a rat model of hindlimb ischemia.8 We also demonstrated that LIPUS improved myocardial ischemia in a pig model of chronic myocardial ischemia to the same extent as low-energy SW therapy.9